منابع مشابه
small science , big hopes
A images of tumor cells being vaporized in beams of colorful light, a video produced by the National Cancer Institute proclaims, “the science is at our fingertips.” The science being referred to, which is 80,000 times smaller than the breadth of a single ridge of skin on a human fingertip, is cancer nanotechnology. Nanotechnology, the study of science on a level the width of ten hydrogen atoms,...
متن کاملA small molecule for a large disease.
n engl j med 358;26 www.nejm.org june 26, 2008 2829 cokinetics and pharmacodynamics of rivaroxaban — an oral, direct factor Xa inhibitor — in patients undergoing major orthopaedic surgery. Clin Pharmacokinet 2008;47:203-16. Guerrini M, Beccati D, Shriver Z, et al. Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events. Nat Biotechnol (in press). Kis...
متن کاملHarnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.
UNLABELLED Identifying genetic alterations that prime a cancer cell to respond to a particular therapeutic agent can facilitate the development of precision cancer medicines. Cancer cell-line (CCL) profiling of small-molecule sensitivity has emerged as an unbiased method to assess the relationships between genetic or cellular features of CCLs and small-molecule response. Here, we developed anno...
متن کاملLarge-scale bioactivity analysis of the small-molecule assayed proteome
This study presents an analysis of the small molecule bioactivity profiles across large quantities of diverse protein families represented in PubChem BioAssay. We compared the bioactivity profiles of FDA approved drugs to non-FDA approved compounds, and report several distinct patterns characteristic of the approved drugs. We found that a large fraction of the previously reported higher target ...
متن کاملβ-phenylethylamine, a small molecule with a large impact.
During a screen of bacterial nutrients as inhibitors of Escherichia coli O157:H7 biofilm, the Prüß research team made an intriguing observation: among 95 carbon and 95 nitrogen sources tested, β-phenylethylamine (PEA) performed best at reducing bacterial cell counts and biofilm amounts, when supplemented to liquid beef broth medium. This review article summarizes what is known about PEA. After ...
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ژورنال
عنوان ژورنال: Internal Medicine Journal
سال: 2001
ISSN: 1444-0903,1445-5994
DOI: 10.1046/j.1445-5994.2001.00096.x